Antioxidant and Protective Effects of Artemisia campestris Essential Oil Against Chlorpyrifos-Induced Kidney and Liver Injuries in Rats

Mongi Saoudi; Riadh Badraoui; Riadh Badraoui; Riadh Badraoui; Fatma Rahmouni; Kamel Jamoussi; Abdelfattah El Feki

doi:10.3389/fphys.2021.618582

Frontiers in Physiology (Feb 2021)

Antioxidant and Protective Effects of Artemisia campestris Essential Oil Against Chlorpyrifos-Induced Kidney and Liver Injuries in Rats

Mongi Saoudi,
Riadh Badraoui,
Riadh Badraoui,
Riadh Badraoui,
Fatma Rahmouni,
Kamel Jamoussi,
Abdelfattah El Feki

Affiliations

Mongi Saoudi: Animal Ecophysiology Laboratory, Sciences Faculty of Sfax, University of Sfax, Sfax, Tunisia
Riadh Badraoui: Department of Biology, University of Hai’l, Ha’il, Saudi Arabia
Riadh Badraoui: Laboratory of Histology - Cytology, Medicine Faculty of Tunis, University of Tunis El Manar, Tunis, Tunisia
Riadh Badraoui: Laboratory of Histo-Embryology and Cytogenetics, Medicine Faculty of Sfax University, Sfax, Tunisia
Fatma Rahmouni: Laboratory of Histo-Embryology and Cytogenetics, Medicine Faculty of Sfax University, Sfax, Tunisia
Kamel Jamoussi: Biochemistry Laboratory, University Hospital Complex (CHU) Hedi Chaker of Sfax, Sfax, Tunisia
Abdelfattah El Feki: Animal Ecophysiology Laboratory, Sciences Faculty of Sfax, University of Sfax, Sfax, Tunisia

DOI: https://doi.org/10.3389/fphys.2021.618582
Journal volume & issue: Vol. 12

Abstract

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This study is aimed to elucidate the possible antioxidant and protective effects of Artemisia campestris essential oil (ACEO) against the deleterious effects of chlorpyrifos (CPF) in rats. The in vivo study revealed increases in aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP) activities and the serum contents of creatinine, urea, uric acid, cholesterol, triglycerides, low density lipoproteins (LDL), and glucose in rats treated with CPF as compared to controls. Meanwhile, hepatic and renal activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in liver and kidney decreased and the content of malondialdehyde (MDA) increased. Some histopathologic features were noticed in liver and kidney of the CPF group. Interestingly, ACEO alleviated the biochemical disruptions and reduced these hepato-renal morphologic changes.

Published in Frontiers in Physiology

ISSN: 1664-042X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Physiology
Website: https://www.frontiersin.org/journals/physiology

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