Progress in genetic research on keratoconus

Abstract

Keratoconus is a corneal disease characterized by corneal ectasia, progressive corneal thinning, conical protrusion and irregular astigmatism. Several studies have indicated that keratoconus is a complex disease with genetic heterogeneity. Genetic studies on keratoconus involving nuclear genome, mitochondrial genome and epigenetics were increasing. This article reviews the recent progress in genetic research on keratoconus.

Keywords

• keratoconus
• genetics
• nuclear genome
• mitochondrial genome
• epigenetics