Nature Communications (Oct 2019)
Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function
- Zehua Bian,
- Qiang Wang,
- Xinyu Zhou,
- Tao Tan,
- Ki Ho Park,
- H. Fritz Kramer,
- Alan McDougal,
- Nicholas J. Laping,
- Sanjay Kumar,
- T. M. Ayodele Adesanya,
- Matthew Sermersheim,
- Frank Yi,
- Xinxin Wang,
- Junwei Wu,
- Kristyn Gumpper,
- Qiwei Jiang,
- Duofen He,
- Pei-Hui Lin,
- Haichang Li,
- Fangxia Guan,
- Jingsong Zhou,
- Mark J. Kohr,
- Chunyu Zeng,
- Hua Zhu,
- Jianjie Ma
Affiliations
- Zehua Bian
- Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University
- Qiang Wang
- Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University
- Xinyu Zhou
- Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University
- Tao Tan
- Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University
- Ki Ho Park
- Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University
- H. Fritz Kramer
- Innate Immunity Research Unit, GlaxoSmithKline, Inc.
- Alan McDougal
- Innate Immunity Research Unit, GlaxoSmithKline, Inc.
- Nicholas J. Laping
- Novel Human Genetics Research Unit, GlaxoSmithKline, Inc.
- Sanjay Kumar
- Novel Human Genetics Research Unit, GlaxoSmithKline, Inc.
- T. M. Ayodele Adesanya
- Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University
- Matthew Sermersheim
- Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University
- Frank Yi
- Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University
- Xinxin Wang
- The First Affiliated Hospital of Zhengzhou University
- Junwei Wu
- The First Affiliated Hospital of Zhengzhou University
- Kristyn Gumpper
- Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University
- Qiwei Jiang
- Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University
- Duofen He
- Department of Cardiology, Daping Hospital, The Third Military Medical University
- Pei-Hui Lin
- Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University
- Haichang Li
- Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University
- Fangxia Guan
- School of Life Sciences, Zhengzhou University
- Jingsong Zhou
- College of Nursing and Health Innovation, University of Texas at Arlington
- Mark J. Kohr
- Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University
- Chunyu Zeng
- Department of Cardiology, Daping Hospital, The Third Military Medical University
- Hua Zhu
- Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University
- Jianjie Ma
- Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University
- DOI
- https://doi.org/10.1038/s41467-019-12483-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
MG53 is a protein that regulates the cell membrane repair process, and it’s been suggested that it might play a role in diabetes. Here, the authors demonstrate that circulating MG53 functions as a myokine to facilitate tissue injury-repair and regeneration without impacting glucose handling.
