Host Transcription Factors in Hepatitis B Virus RNA Synthesis

Kristi  L. Turton; Vanessa Meier-Stephenson; Maulik  D. Badmalia; Carla  S. Coffin; Trushar  R. Patel

doi:10.3390/v12020160

Viruses (Jan 2020)

Host Transcription Factors in Hepatitis B Virus RNA Synthesis

Kristi L. Turton,
Vanessa Meier-Stephenson,
Maulik D. Badmalia,
Carla S. Coffin,
Trushar R. Patel

Affiliations

Kristi L. Turton: Alberta RNA Research and Training Institute, Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Dr. W., Lethbridge, AB T1K 3M4, Canada
Vanessa Meier-Stephenson: Alberta RNA Research and Training Institute, Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Dr. W., Lethbridge, AB T1K 3M4, Canada
Maulik D. Badmalia: Alberta RNA Research and Training Institute, Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Dr. W., Lethbridge, AB T1K 3M4, Canada
Carla S. Coffin: Department of Microbiology, Immunology and Infectious Diseases, Cumming, School of Medicine, University of Calgary, 2500 University Dr. N.W., Calgary, AB T2N 1N4, Canada
Trushar R. Patel: Alberta RNA Research and Training Institute, Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Dr. W., Lethbridge, AB T1K 3M4, Canada

DOI: https://doi.org/10.3390/v12020160
Journal volume & issue: Vol. 12, no. 2
p. 160

Abstract

Read online

The hepatitis B virus (HBV) chronically infects over 250 million people worldwide and is one of the leading causes of liver cancer and hepatocellular carcinoma. HBV persistence is due in part to the highly stable HBV minichromosome or HBV covalently closed circular DNA (cccDNA) that resides in the nucleus. As HBV replication requires the help of host transcription factors to replicate, focusing on host protein−HBV genome interactions may reveal insights into new drug targets against cccDNA. The structural details on such complexes, however, remain poorly defined. In this review, the current literature regarding host transcription factors’ interactions with HBV cccDNA is discussed.

Published in Viruses

ISSN: 1999-4915 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.mdpi.com/journal/viruses

About the journal

Abstract

Keywords