Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2

Antoni G. Wrobel; Donald J. Benton; Pengqi Xu; Lesley J. Calder; Annabel Borg; Chloë Roustan; Stephen R. Martin; Peter B. Rosenthal; John J. Skehel; Steven J. Gamblin

doi:10.1038/s41467-021-21006-9

Nature Communications (Feb 2021)

Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2

Antoni G. Wrobel,
Donald J. Benton,
Pengqi Xu,
Lesley J. Calder,
Annabel Borg,
Chloë Roustan,
Stephen R. Martin,
Peter B. Rosenthal,
John J. Skehel,
Steven J. Gamblin

Affiliations

Antoni G. Wrobel: Structural Biology of Disease Processes Laboratory, Francis Crick Institute, NW1 1AT
Donald J. Benton: Structural Biology of Disease Processes Laboratory, Francis Crick Institute, NW1 1AT
Pengqi Xu: Structural Biology of Disease Processes Laboratory, Francis Crick Institute, NW1 1AT
Lesley J. Calder: Structural Biology of Cells and Viruses Laboratory, Francis Crick Institute, NW1 1AT
Annabel Borg: Structural Biology Science Technology Platform, Francis Crick Institute, NW1 1AT
Chloë Roustan: Structural Biology Science Technology Platform, Francis Crick Institute, NW1 1AT
Stephen R. Martin: Structural Biology of Disease Processes Laboratory, Francis Crick Institute, NW1 1AT
Peter B. Rosenthal: Structural Biology of Cells and Viruses Laboratory, Francis Crick Institute, NW1 1AT
John J. Skehel: Structural Biology of Disease Processes Laboratory, Francis Crick Institute, NW1 1AT
Steven J. Gamblin: Structural Biology of Disease Processes Laboratory, Francis Crick Institute, NW1 1AT

DOI: https://doi.org/10.1038/s41467-021-21006-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 6

Abstract

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It has been suggested that pangolin coronaviruses may be the origin of SARS-CoV-2. Here the authors show that the Pangolin-CoV spike is structurally closely related to the closed form of SARS-CoV-2 spike and exhibits similar binding properties to human and pangolin ACE2; although neither spike binds bat ACE2.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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