Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system

Nathan H. Kipniss; P. C. Dave P. Dingal; Timothy R. Abbott; Yuchen Gao; Haifeng Wang; Antonia A. Dominguez; Louai Labanieh; Lei S. Qi

doi:10.1038/s41467-017-02075-1

Nature Communications (Dec 2017)

Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system

Nathan H. Kipniss,
P. C. Dave P. Dingal,
Timothy R. Abbott,
Yuchen Gao,
Haifeng Wang,
Antonia A. Dominguez,
Louai Labanieh,
Lei S. Qi

Affiliations

Nathan H. Kipniss: Department of Bioengineering, Stanford University
P. C. Dave P. Dingal: Department of Bioengineering, Stanford University
Timothy R. Abbott: Department of Bioengineering, Stanford University
Yuchen Gao: Cancer Biology Program, Stanford University
Haifeng Wang: Department of Bioengineering, Stanford University
Antonia A. Dominguez: Department of Bioengineering, Stanford University
Louai Labanieh: Department of Bioengineering, Stanford University
Lei S. Qi: Department of Bioengineering, Stanford University

DOI: https://doi.org/10.1038/s41467-017-02075-1
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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G-protein-coupled receptors are a large and diverse group of eukaryotic membrane receptors. Here the authors couple GPCRs to dCas9 to link extracellular sensing to genome regulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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