Nature Communications (May 2019)
The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models
- Naiara Martínez-Vélez,
- Marc Garcia-Moure,
- Miguel Marigil,
- Marisol González-Huarriz,
- Montse Puigdelloses,
- Jaime Gallego Pérez-Larraya,
- Marta Zalacaín,
- Lucía Marrodán,
- Maider Varela-Guruceaga,
- Virginia Laspidea,
- Jose Javier Aristu,
- Luis Isaac Ramos,
- Sonia Tejada-Solís,
- Ricardo Díez-Valle,
- Chris Jones,
- Alan Mackay,
- Jose A. Martínez-Climent,
- Maria Jose García-Barchino,
- Eric Raabe,
- Michelle Monje,
- Oren J. Becher,
- Marie Pierre Junier,
- Elias A. El-Habr,
- Herve Chneiweiss,
- Guillermo Aldave,
- Hong Jiang,
- Juan Fueyo,
- Ana Patiño-García,
- Candelaria Gomez-Manzano,
- Marta M. Alonso
Affiliations
- Naiara Martínez-Vélez
- Health Research Institute of Navarra (IDISNA)
- Marc Garcia-Moure
- Health Research Institute of Navarra (IDISNA)
- Miguel Marigil
- Health Research Institute of Navarra (IDISNA)
- Marisol González-Huarriz
- Health Research Institute of Navarra (IDISNA)
- Montse Puigdelloses
- Health Research Institute of Navarra (IDISNA)
- Jaime Gallego Pérez-Larraya
- Health Research Institute of Navarra (IDISNA)
- Marta Zalacaín
- Health Research Institute of Navarra (IDISNA)
- Lucía Marrodán
- Health Research Institute of Navarra (IDISNA)
- Maider Varela-Guruceaga
- Health Research Institute of Navarra (IDISNA)
- Virginia Laspidea
- Health Research Institute of Navarra (IDISNA)
- Jose Javier Aristu
- Health Research Institute of Navarra (IDISNA)
- Luis Isaac Ramos
- Health Research Institute of Navarra (IDISNA)
- Sonia Tejada-Solís
- Health Research Institute of Navarra (IDISNA)
- Ricardo Díez-Valle
- Health Research Institute of Navarra (IDISNA)
- Chris Jones
- Division of Molecular Pathology, The Institute of Cancer Research
- Alan Mackay
- Division of Molecular Pathology, The Institute of Cancer Research
- Jose A. Martínez-Climent
- Health Research Institute of Navarra (IDISNA)
- Maria Jose García-Barchino
- Health Research Institute of Navarra (IDISNA)
- Eric Raabe
- Department of Pathology, The Johns Hopkins University School of Medicine
- Michelle Monje
- Department of Neurology, Stanford University School of Medicine
- Oren J. Becher
- Department of Pediatrics, Northwestern University and Division of Pediatric Hematology-Oncology and Stem Cell Transplant, Ann & Robert H. Lurie Children’s Hospital
- Marie Pierre Junier
- CNRS UMR8246, Inserm U1130, Neuroscience Paris Seine - IBPS, Sorbonne Universities
- Elias A. El-Habr
- CNRS UMR8246, Inserm U1130, Neuroscience Paris Seine - IBPS, Sorbonne Universities
- Herve Chneiweiss
- CNRS UMR8246, Inserm U1130, Neuroscience Paris Seine - IBPS, Sorbonne Universities
- Guillermo Aldave
- Division of Pediatric Neurosurgery, Department of Surgery, Texas Children’s Hospital, Baylor College of Medicine
- Hong Jiang
- Department of NeuroOncology, The University of Texas MD Anderson Cancer Center
- Juan Fueyo
- Department of NeuroOncology, The University of Texas MD Anderson Cancer Center
- Ana Patiño-García
- Health Research Institute of Navarra (IDISNA)
- Candelaria Gomez-Manzano
- Department of NeuroOncology, The University of Texas MD Anderson Cancer Center
- Marta M. Alonso
- Health Research Institute of Navarra (IDISNA)
- DOI
- https://doi.org/10.1038/s41467-019-10043-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
The oncolytic virus Delta-24-RGD is in clinical trial for adult glioma. Here, the authors show that this virus elicits an immune response in mouse models of pediatric high-grade glioma and diffuse pontine intrinsic glioma, resulting in improved survival.
