Association between interleukin-1 beta gene, interleukin-1 receptor antagonist gene polymorphisms and urolithiasis: A literature review and meta-analysis

Abstract

Several case-control studies have been performed in different populations to uncover the association between interleukin-1 beta gene, interleukin-1 receptor antagonist gene polymorphisms and urolithiasis. Here we decided to perform a literature review and meta-analysis to further estimate it. A systematic search was conducted in PubMed, Embase, Cochrane, clinicaltrials.gov, CNKI databases. To pool the effect size, odds ratios and 95% confidence intervals were used. Finally, five articles were included. Our results of literature review suggested that IL1RN IVS2 VNTR might be associated with the risk of urolithiasis. However, the results of meta-analysis suggested that IL-1beta -511C>T, IL-1beta +3954C>T, and IL1RN IVS2 VNTR might not be associated with the risk of urolithiasis. There were not enough data to fully confirm this association and the results should be interpreted with caution.