Effect of resistance training on FOXO1 gene expression in subcutaneous fatty tissue in diabetic wistar rats

Abstract

Background and Objective: Hormone and genetic disorders are the most important causes of hyperglycemia in obese and diabetes patients. This study was done to determine the effect of the resistance training program on FOXO1 gene expression in subcutaneous adipose tissue as an effective transcription factor in insulin signaling pathways, fasting glucose and insulin resistance in type 2 diabetic rats. Methods: In this experimental study, type 2 diabetes induced by high fat diet and Streptozotocin (STZ, 30 mg/kg/bw) intraperitoneal injection in 14 male wistar rats (220±20 g) .Animals were randomly allocated into exercise (n=7) and control (n=7) groups. Exercise group were participated in resistance training program (6 weeks, 5 days/weekly). Fasting blood glucose and insulin as well FOXO1 gene expression in subcutaneous adipose tissue were measured lasted exercise session in the two geoups. Results: Resistance training significantly reduces in fasting glucose, insulin resistance and FOXO1 gene expression in subcutaneous adipose tissue in exercise group in compared to control group (P<0.05). Conclusion: Resistance training lead to decrease of insulin resistance and blood glucose by inhibiting FOXO1 gene expression in subcutaneous adipose tissue in diabetic rats.

Keywords

• resistance training
• foxo1 gene
• fasting glucose
• type 2 diabetes