3β,11α-Dihydroxy-17a-oxa-d-homoandrost-5-en-17-one

Abstract

The title compound, C19H28O4, was prepared from DHEA (dehydroepiandrosterone) by its biotransformation using whole cells of the filamentous fungus Beauveria bassiana. The asymmetric unit contains two molecules. The lactone ring is trans-positioned to the neighboring six-membered ring. In the crystal structure, O—H...O hydrogen bonds form layers, which are linked to each other by O—H...O and C—H...O hydrogen bonds.