Морфологія (Mar 2015)
The dynamics of morphological changes of facial skin in patients with malasseziasis at stages of antimycotic and anti-aging therapy
Abstract
Background. Many questions about the dependence of pathological changes of the skin to age-appropriate background malassezia destruction require clarification and further advance, as well as the dependence of the effectiveness of anti-aging interventions of antimycotic therapy. Objective. The purpose of this study was to determine the morphological changes of the skin in patients with malasseziasis on stages of antimitotic and anti-aging therapy. Methods. In 90 patients with involutive changes in facial skin, including 60 patients with malasseziasis, using electron microscopy carried determine the state of the skin. Results. Found that specific antifungal therapy for 1 month prior to surgical intervention in the face provides the normalization of skin structures damaged by keratomicosis, through emulation of mitotic activity of keratinocytes in germinal zone and optimizing epidermal differentiation restricted vacuolization of epithelial cells. Prolongation of local and systemic antimycotic therapy within 1 month after the intervention was accompanied by reduction of involutive morphological changes of the skin and prevents development of malasseziasis recurrent for 1 year. Conclusion. Specific antimycotic therapy in patients with malasseziasis is essential for achieving high performance anti-aging activities. Citation: Makarchuk AO. [The dynamics of morphological changes of facial skin in patients with malasseziasis at stages of antimycotic and anti-aging therapy]. Morphologia. 2015;9(1):39-46. Ukrainian.
