mSphere of Influence: Stromal Regulation of Epithelium Containing Viral Oncogenes

Abstract

ABSTRACT Jason Bodily works in the field of tumor virology. In this mSphere of Influence article, he reflects on how “Inactivation of Rb in stromal fibroblasts promotes epithelial cell invasion” by Adam Pickard et al. (EMBO J 31:3092–3103, 2012, https://doi.org/10.1038/emboj.2012.153) has impacted his work by making him think about the role of stromal cells in human papillomavirus infections.

Keywords

• fibroblasts
• keratinocytes
• organotypic culture
• papillomavirus
• retinoblastoma
• stroma