EVALUATION OF HAEMATO-BIOCHEMICAL ALTERATIONS IN CHLORPYRIFOS TOXICITY IN RATS AND THE PROTECTIVE ROLE OF VITAMIN C

Abstract

The study aimed at assessing the protective effect of vitamin C on chlorpyrifos toxicity. Eighteen rats were divided into three groups each with six rats. Group І serving as control was administered with the vehicle tween 80 as 2% aq. solution. Chlorpyrifos was administered at a dose rate of 3.1mg/kg body weight in groups ІІ and ІІІ and Vitamin C (120µg/ kg)was supplemented to group ІІІ. The regimen was administered by oral gavage once daily for 28 days. While in the chlorpyrifos treated group the blood mean values of haemoglobin, volume of packed red cells, leukocytes and red blood cells were lowered, the vitamin C treated group revealed enhancement in these values. The altered serum parameters like AST and ALT in chlorpyrifos treated animals were also restored in vitamin C treated group. The study highlights that the adverse effects of chlorpyrifos toxicity on haemato-biochemical parameters of rats could be mitigated by treatment with vitamin C

Keywords

• chlorpyrifos
• vitamin c
• haematobiochemical parameters