A case of symmetrical drug-related intertriginous and flexural exanthema caused by valacyclovir

Abstract

Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) has recently been separated from baboon syndrome and proposed as a unique type of drug eruption [1], which appears only on intertriginous or flexural folds and in gluteal areas in the absence of systemic involvement. Antibiotics including amoxicillin and cephalosporins are the most common drugs causing SDRIFE [2]. We report herein a case of SDRIFE showing symmetrical erythema predominantly on major flexural areas, rapidly developed after taking valacyclovir, which was suggested as a causative drug by skin patch test.

Keywords

• valacyclovir
• SDRIFE
• skin patch test