Foods (Jul 2024)

Korean Red Ginseng Improves Oxidative Stress-Induced Hepatic Insulin Resistance via Enhancing Mitophagy

  • Nodir Rustamov,
  • Yuanqiang Ma,
  • Jeong-Su Park,
  • Feng Wang,
  • Hwan Ma,
  • Guoyan Sui,
  • Gahye Moon,
  • Hwan-Soo Yoo,
  • Yoon-Seok Roh

DOI
https://doi.org/10.3390/foods13132137
Journal volume & issue
Vol. 13, no. 13
p. 2137

Abstract

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This study explored the potential of saponins from Korean Red Ginseng to target the PINK1/Parkin mitophagy pathway, aiming to enhance insulin sensitivity in hepatocytes—a key factor in metabolic disorders like metabolic dysfunction-associated steatotic liver disease (MASLD) and type 2 diabetes. Results from both in vitro and in vivo experiments showed increased expression of PINK1 and Parkin, activating mitophagy and reducing oxidative stress through reduction in mitochondrial and total reactive oxygen species. Additionally, improvements in insulin signaling were observed, including the upregulation of phosphorylated IRS and AKT, and downregulation of gluconeogenic enzymes, underscoring the saponins’ efficacy in boosting insulin sensitivity. The findings highlighted Korean Red Ginseng-derived saponins as potential treatments for insulin resistance and related metabolic conditions.

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