An investigation of a palladium catalysed biaryl synthesis of pyrrolophenanthridine derivatives. Extension of the Heck reaction

Abstract

N-Benzylisatin derivatives have been found to readily undergo cyclisation via hydrogen halide elimination in a biaryl synthesis reaction when using palladium catalysts, in the absence of phosphine ligands, to yield oxopyrrolo[3,2,1-de]phenanthridine derivatives.

Keywords

• Heck reaction (Jeffery's conditions)
• benzylisatins
• pyrrolophenanthridines
• biaryl coupling