Assessment of serum soluble CD40 ligand levels in patients with chronic rhinosinusitis

Zhichen Liu, MD; Yuhui Fan, MD; Aina Zhou, MD; Jisheng Liu, MD; Qingqing Jiao, PhD

World Allergy Organization Journal (Mar 2024)

Assessment of serum soluble CD40 ligand levels in patients with chronic rhinosinusitis

Zhichen Liu, MD,
Yuhui Fan, MD,
Aina Zhou, MD,
Jisheng Liu, MD,
Qingqing Jiao, PhD

Affiliations

Zhichen Liu, MD: Department of Ear, Nose, and Throat, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China
Yuhui Fan, MD: Department of Ear, Nose, and Throat, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China
Aina Zhou, MD: Department of Ear, Nose, and Throat, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China
Jisheng Liu, MD: Department of Ear, Nose, and Throat, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China; Corresponding author. The First Affiliated Hospital of Soochow University Dept. of Ear, Nose, and Throat Shizi Road 188, 215006 Suzhou, China.
Qingqing Jiao, PhD: Department of Dermatology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China; Corresponding author. The First Affiliated Hospital of Soochow University Dept. of Dermatology, Shizi Road 188, 215006 Suzhou, China.

Journal volume & issue: Vol. 17, no. 3
p. 100880

Abstract

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Chronic rhinosinusitis (CRS) is a disease highly associated with abnormal regulation of T and B cells. The underlying pathophysiology of inflammatory pathways has critical implications for the diagnosis and management of CRS. Soluble CD40-ligand (sCD40L) is a cleaved form of CD40L present in plasma which functions the same way as CD40L, which has been observed as an inflammatory biomarker in many diseases. CD40L-positive cells control B-cell maturation, proliferation, apoptosis, and antibody production by binding to its receptor CD40 on B-cells. And our results show for the first time that patients with CRS have lower serum sCD40L levels compared to healthy subjects and that decreased sCD40L levels in patients correlate with increased CD40L-positive cell counts in the sinonasal mucosa. In addition, eosinophilic chronic rhinosinusitis (eCRS) patients tend to exhibit more CD40L-positive cells in the sinonasal mucosa compared to non-eCRS patients. This supports the notion that local blockade of CD40/CD40L may suppress pathogenic T/B cell responses and reduce tissue inflammation. Significantly, sCD40L and CD40L may be involved in the development and progression of CRS by impairing peripheral blood B-cell function and enhancing the local inflammatory response in the sinonasal mucosa.

Published in World Allergy Organization Journal

ISSN: 1939-4551 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.sciencedirect.com/journal/world-allergy-organization-journal

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