Nature Communications (Oct 2022)
Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape
- Maurizio Mangolini,
- Alba Maiques-Diaz,
- Stella Charalampopoulou,
- Elena Gerhard-Hartmann,
- Johannes Bloehdorn,
- Andrew Moore,
- Giorgia Giachetti,
- Junyan Lu,
- Valar Nila Roamio Franklin,
- Chandra Sekkar Reddy Chilamakuri,
- Ilias Moutsopoulos,
- Andreas Rosenwald,
- Stephan Stilgenbauer,
- Thorsten Zenz,
- Irina Mohorianu,
- Clive D’Santos,
- Silvia Deaglio,
- Daniel J. Hodson,
- Jose I. Martin-Subero,
- Ingo Ringshausen
Affiliations
- Maurizio Mangolini
- Wellcome/MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge
- Alba Maiques-Diaz
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Stella Charalampopoulou
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Elena Gerhard-Hartmann
- Pathologisches Institut Universität Würzburg
- Johannes Bloehdorn
- Department of Internal Medicine III, Division of CLL, Ulm University
- Andrew Moore
- Wellcome/MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge
- Giorgia Giachetti
- Wellcome/MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge
- Junyan Lu
- European Molecular Biology Laboratory (EMBL)
- Valar Nila Roamio Franklin
- Cancer Research UK Cambridge Institute, University of Cambridge
- Chandra Sekkar Reddy Chilamakuri
- Cancer Research UK Cambridge Institute, University of Cambridge
- Ilias Moutsopoulos
- Wellcome/MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge
- Andreas Rosenwald
- Pathologisches Institut Universität Würzburg
- Stephan Stilgenbauer
- Department of Internal Medicine III, Division of CLL, Ulm University
- Thorsten Zenz
- Department of Medical Oncology and Hematology, University Hospital Zürich and University of Zürich
- Irina Mohorianu
- Wellcome/MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge
- Clive D’Santos
- Cancer Research UK Cambridge Institute, University of Cambridge
- Silvia Deaglio
- Department of Medical Sciences, University of Turin
- Daniel J. Hodson
- Wellcome/MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge
- Jose I. Martin-Subero
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Ingo Ringshausen
- Wellcome/MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-022-33739-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 21
Abstract
NOTCH mutations are frequent in B cell malignancies. Here the authors use retroviral transduction of primary malignant B cells from Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL) patients to show that NOTCH1/2-mutations facilitate mechanism of immune escape.
