Opportunisticheskaya gerpes-virusnaya infektsiya v patogeneze uveitov u detey s yuvenil'nym khronicheskim artritom

Abstract

Objective. To reveal frequency of reactivation of persistent HSV type 1, 2 and CMV infections and to estimate its role in pathogenesis of rheumatoid uveitis in children with JCA. Material and methods. 61 children with RU at the age of 5 - 15 years were studied. The duration of disease: 6 months - 13 years. Serum samples were tested in commercial enzyme linked immunnosorbent assay for detection of antibodies to unstructural early herpesviruses proteins (serologic evidence of acute infection). Cell-mediated immunity to HSV was measured by the in vitro proliferated response of peripheral lymphocytes (LP). Results. Reactivation of HSV and/or CMV persistent infections was established in 30 of 61 surveyed children (49 %) with RU. The activation of HSV type 1 infection (34,4 % of the patients) dominated. The antibodies to unstructured early HSV type 2 protein were detected in 8,2 %, to CMV- in 5 % of children. Conclusion. The correlation was observed between results of serologic investigations and clinical signs of RU.

Keywords

• juvenile chronic arthritis
• uveitis
• herpesviruses
• cytomegalovirus