Natural bioactive compounds in Alzheimer's disease: From the perspective of type 3 diabetes mellitus

Juan Huang; Juan Huang; Juan Huang; Nanqu Huang; Qianhua Mao; Jingshan Shi; Yu Qiu

doi:10.3389/fnagi.2023.1130253

Frontiers in Aging Neuroscience (Mar 2023)

Natural bioactive compounds in Alzheimer's disease: From the perspective of type 3 diabetes mellitus

Juan Huang,
Juan Huang,
Juan Huang,
Nanqu Huang,
Qianhua Mao,
Jingshan Shi,
Yu Qiu

Affiliations

Juan Huang: Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Juan Huang: Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Lab of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, China
Juan Huang: School of Public Health, Zunyi Medical University, Zunyi, Guizhou, China
Nanqu Huang: National Drug Clinical Trial Institution, Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, Guizhou, China
Qianhua Mao: Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Lab of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, China
Jingshan Shi: Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Lab of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, China
Yu Qiu: Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China

DOI: https://doi.org/10.3389/fnagi.2023.1130253
Journal volume & issue: Vol. 15

Abstract

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There is a close relationship between Alzheimer's disease (AD) and diabetes mellitus (DM), and the link between the two is often referred to as type 3 diabetes mellitus (T3DM). Many natural bioactive compounds have shown the potential to treat AD and diabetes. We mainly review the polyphenols represented by resveratrol (RES) and proanthocyanidins (PCs) and alkaloids represented by berberine (BBR) and Dendrobium nobile Lindl. alkaloids (DNLA) from the perspective of T3DM to review the neuroprotective effects and molecular mechanisms of natural compounds in AD.

Published in Frontiers in Aging Neuroscience

ISSN: 1663-4365 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.frontiersin.org/journals/aging-neuroscience

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