CHIMIA (Sep 2004)

2-Styryl-pyridines and 2-(3,4-Dihydro-naphthalen-2-yl)pyridines as Potent NR1/2B Subtype Selective NMDA Receptor Antagonists

  • Bernd Buettelmann,
  • Alexander Alanine,
  • Anne Bourson,
  • Ramanjit Gill,
  • Marie-Paule Heitz,
  • Vincent Mutel,
  • Emmanuel Pinard,
  • Gerhard Trube,
  • René Wyler

DOI
https://doi.org/10.2533/000942904777677579
Journal volume & issue
Vol. 58, no. 9

Abstract

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A series of 2-styryl-pyridines and 2-(3,4-dihydro-naphthalen-2-yl)-pyridines was prepared and evaluated as NR1/2B subtype selective NMDA receptor antagonists. The SAR developed in this series resulted in the discovery of high affinity antagonists that are selective (vs. ?1 and M1 receptors) and are active in vivo .

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