Briarenols I—K, New Anti-inflammatory 8,17-Epoxybriaranes from the Octocoral <i>Briareum excavatum</i> (Briareidae)

Abstract

Five 8,17-epoxybriaranes, including three new compounds—briarenols I−K (1−3), along with two known analogues, briaexcavatolide P (4) and briaexcavatin P (5), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1−3 were elucidated by spectroscopic methods, including 1D and 2D NMR studies and (+)-HRESIMS. Briarane 4 exerted inhibition effects on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) release from RAW 264.7.

Keywords

• <i>briareum excavatum</i>
• briarenol
• briarane
• anti-inflammatory
• inos
• cox-2