Nature Communications (May 2019)
The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function
- Allison J. Bancroft,
- Colin W. Levy,
- Thomas A. Jowitt,
- Kelly S. Hayes,
- Seona Thompson,
- Edward A. Mckenzie,
- Matthew D. Ball,
- Eamon Dubaissi,
- Aidan P. France,
- Bruno Bellina,
- Catherine Sharpe,
- Aleksandr Mironov,
- Sheila L. Brown,
- Peter C. Cook,
- Andrew S. MacDonald,
- David J. Thornton,
- Richard K. Grencis
Affiliations
- Allison J. Bancroft
- Lydia Becker Institute for Immunology and Inflammation
- Colin W. Levy
- Manchester Institute of Biotechnology, University of Manchester
- Thomas A. Jowitt
- Wellcome Trust Centre for Cell Matrix Research
- Kelly S. Hayes
- Lydia Becker Institute for Immunology and Inflammation
- Seona Thompson
- Lydia Becker Institute for Immunology and Inflammation
- Edward A. Mckenzie
- Manchester Institute of Biotechnology, University of Manchester
- Matthew D. Ball
- Manchester Institute of Biotechnology, University of Manchester
- Eamon Dubaissi
- Lydia Becker Institute for Immunology and Inflammation
- Aidan P. France
- Manchester Institute of Biotechnology, University of Manchester
- Bruno Bellina
- Manchester Institute of Biotechnology, University of Manchester
- Catherine Sharpe
- Lydia Becker Institute for Immunology and Inflammation
- Aleksandr Mironov
- School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester
- Sheila L. Brown
- Lydia Becker Institute for Immunology and Inflammation
- Peter C. Cook
- Lydia Becker Institute for Immunology and Inflammation
- Andrew S. MacDonald
- Lydia Becker Institute for Immunology and Inflammation
- David J. Thornton
- Lydia Becker Institute for Immunology and Inflammation
- Richard K. Grencis
- Lydia Becker Institute for Immunology and Inflammation
- DOI
- https://doi.org/10.1038/s41467-019-09996-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
In the study, the authors identify a protein excreted by the parasite Trichuris muris, p43, which can modulate IL-13 function, a key cytokine involved in host protection. These data suggest that p43 may be a novel therapeutic target for both whipworm infections and IL13 mediated pathologies.
