Nature Communications (Jul 2020)

Global translation during early development depends on the essential transcription factor PRDM10

  • Brenda Y. Han,
  • Michelle K. Y. Seah,
  • Imogen R. Brooks,
  • Delia H. P. Quek,
  • Dominic R. Huxley,
  • Chuan-Sheng Foo,
  • Li Ting Lee,
  • Heike Wollmann,
  • Huili Guo,
  • Daniel M. Messerschmidt,
  • Ernesto Guccione

DOI
https://doi.org/10.1038/s41467-020-17304-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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PRDM family members are transcriptional regulators involved in cell identity and fate determination. Here, the authors characterize PRDM10 and show that it functions to ensure global translation efficiency during early embryonic development.