Frontiers in Genetics (Oct 2021)
Gene4HL: An Integrated Genetic Database for Hearing Loss
- Shasha Huang,
- Shasha Huang,
- Shasha Huang,
- Guihu Zhao,
- Guihu Zhao,
- Jie Wu,
- Jie Wu,
- Jie Wu,
- Kuokuo Li,
- Kuokuo Li,
- Qiuquan Wang,
- Qiuquan Wang,
- Qiuquan Wang,
- Ying Fu,
- Ying Fu,
- Ying Fu,
- Honglei Zhang,
- Honglei Zhang,
- Honglei Zhang,
- Qingling Bi,
- Qingling Bi,
- Qingling Bi,
- Xiaohong Li,
- Xiaohong Li,
- Xiaohong Li,
- Weiqian Wang,
- Weiqian Wang,
- Weiqian Wang,
- Chang Guo,
- Chang Guo,
- Chang Guo,
- Dejun Zhang,
- Dejun Zhang,
- Dejun Zhang,
- Lihua Wu,
- Lihua Wu,
- Lihua Wu,
- Xiaoge Li,
- Xiaoge Li,
- Xiaoge Li,
- Huiyan Xu,
- Huiyan Xu,
- Huiyan Xu,
- Mingyu Han,
- Mingyu Han,
- Mingyu Han,
- Xin Wang,
- Chen Lei,
- Xiaofang Qiu,
- Yang Li,
- Jinchen Li,
- Jinchen Li,
- Pu Dai,
- Pu Dai,
- Pu Dai,
- Yongyi Yuan,
- Yongyi Yuan,
- Yongyi Yuan
Affiliations
- Shasha Huang
- College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China
- Shasha Huang
- National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Shasha Huang
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- Guihu Zhao
- National Clinical Research Center for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, China
- Guihu Zhao
- Center for Medical Genetics & Hunan Key Laboratory, School of Life Sciences, Central South University, Changsha, China
- Jie Wu
- College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China
- Jie Wu
- National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Jie Wu
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- Kuokuo Li
- National Clinical Research Center for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, China
- Kuokuo Li
- Center for Medical Genetics & Hunan Key Laboratory, School of Life Sciences, Central South University, Changsha, China
- Qiuquan Wang
- College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China
- Qiuquan Wang
- National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Qiuquan Wang
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- Ying Fu
- College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China
- Ying Fu
- National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Ying Fu
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- Honglei Zhang
- College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China
- Honglei Zhang
- National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Honglei Zhang
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- Qingling Bi
- College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China
- Qingling Bi
- National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Qingling Bi
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- Xiaohong Li
- College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China
- Xiaohong Li
- National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Xiaohong Li
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- Weiqian Wang
- College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China
- Weiqian Wang
- National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Weiqian Wang
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- Chang Guo
- College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China
- Chang Guo
- National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Chang Guo
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- Dejun Zhang
- College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China
- Dejun Zhang
- National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Dejun Zhang
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- Lihua Wu
- College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China
- Lihua Wu
- National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Lihua Wu
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- Xiaoge Li
- College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China
- Xiaoge Li
- National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Xiaoge Li
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- Huiyan Xu
- College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China
- Huiyan Xu
- National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Huiyan Xu
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- Mingyu Han
- College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China
- Mingyu Han
- National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Mingyu Han
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- Xin Wang
- Angen Gene Medicine Technology Co., Ltd., Beijing, China
- Chen Lei
- Angen Gene Medicine Technology Co., Ltd., Beijing, China
- Xiaofang Qiu
- Angen Gene Medicine Technology Co., Ltd., Beijing, China
- Yang Li
- Angen Gene Medicine Technology Co., Ltd., Beijing, China
- Jinchen Li
- National Clinical Research Center for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, China
- Jinchen Li
- Center for Medical Genetics & Hunan Key Laboratory, School of Life Sciences, Central South University, Changsha, China
- Pu Dai
- College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China
- Pu Dai
- National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Pu Dai
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- Yongyi Yuan
- College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China
- Yongyi Yuan
- National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Yongyi Yuan
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- DOI
- https://doi.org/10.3389/fgene.2021.773009
- Journal volume & issue
-
Vol. 12
Abstract
Hearing loss (HL) is one of the most common disabilities in the world. In industrialized countries, HL occurs in 1–2/1,000 newborns, and approximately 60% of HL is caused by genetic factors. Next generation sequencing (NGS) has been widely used to identify many candidate genes and variants in patients with HL, but the data are scattered in multitudinous studies. It is a challenge for scientists, clinicians, and biologists to easily obtain and analyze HL genes and variant data from these studies. Thus, we developed a one-stop database of HL-related genes and variants, Gene4HL (http://www.genemed.tech/gene4hl/), making it easy to catalog, search, browse and analyze the genetic data. Gene4HL integrates the detailed genetic and clinical data of 326 HL-related genes from 1,608 published studies, along with 62 popular genetic data sources to provide comprehensive knowledge of candidate genes and variants associated with HL. Additionally, Gene4HL supports the users to analyze their own genetic engineering network data, performs comprehensive annotation, and prioritizes candidate genes and variations using custom parameters. Thus, Gene4HL can help users explain the function of HL genes and the clinical significance of variants by correlating the genotypes and phenotypes in humans.
Keywords
