TORC1 modulation in adipose tissue is required for organismal adaptation to hypoxia in Drosophila

Byoungchun Lee; Elizabeth C. Barretto; Savraj S. Grewal

doi:10.1038/s41467-019-09643-7

Nature Communications (Apr 2019)

TORC1 modulation in adipose tissue is required for organismal adaptation to hypoxia in Drosophila

Byoungchun Lee,
Elizabeth C. Barretto,
Savraj S. Grewal

Affiliations

Byoungchun Lee: Clark H Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Alberta Children’s Hospital Research Institute, and Department of Biochemistry and Molecular Biology Calgary, University of Calgary
Elizabeth C. Barretto: Clark H Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Alberta Children’s Hospital Research Institute, and Department of Biochemistry and Molecular Biology Calgary, University of Calgary
Savraj S. Grewal: Clark H Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Alberta Children’s Hospital Research Institute, and Department of Biochemistry and Molecular Biology Calgary, University of Calgary

DOI: https://doi.org/10.1038/s41467-019-09643-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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The hypoxia response pathway couples oxygen availability to physiological adaptations. Using the model system Drosophila melanogaster, here the authors show that hypoxia inhibits TORC1 signalling and increases lipid levels in the larval fat body and that these effects are required for development to adulthood.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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