RUDN Journal of Medicine (Dec 2014)

Expression of matrix metalloproteinase-9 and protein KI-67 at prostate tumors

  • M I Andrukhin,
  • S A Pul’bere,
  • A V Loktev,
  • I I Babichenko

Journal volume & issue
Vol. 0, no. 2
pp. 46 – 51

Abstract

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Iimmunohistochemical study of cells proliferative activity by Ki-67 protein and localization of matrix metalloproteinase-9 has been carried out at benign prostatic hyperplasia (BPH) and adenocarcinoma (AC) of different gradations by the Gleason score. A significant decrease of the MMP-9 levels in the AC of different gradations have been found. A moderate positive correlation between the Gleason score and cell proliferation Ki-67 index (rs = 0,674) and a moderate negative correlation with the level of such score and expression of matrix metalloproteinase-9 (rs = -0,660) were detected. A weak significant negative correlation exists also between the level of proliferative activity of secretory cells and the expression of MMP-9 by tumor cell (rs = -0,369).

Keywords