Single-molecule analysis of specificity and multivalency in binding of short linear substrate motifs to the APC/C

Nairi Hartooni; Jongmin Sung; Ankur Jain; David O. Morgan

doi:10.1038/s41467-022-28031-2

Nature Communications (Jan 2022)

Single-molecule analysis of specificity and multivalency in binding of short linear substrate motifs to the APC/C

Nairi Hartooni,
Jongmin Sung,
Ankur Jain,
David O. Morgan

Affiliations

Nairi Hartooni: Department of Physiology, University of California
Jongmin Sung: Department of Cellular and Molecular Pharmacology, University of California
Ankur Jain: Department of Cellular and Molecular Pharmacology, University of California
David O. Morgan: Department of Physiology, University of California

DOI: https://doi.org/10.1038/s41467-022-28031-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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The authors used novel single-molecule technology to measure the affinity of interactions between the ubiquitin ligase APC/C and its substrates, providing insights into the control of APC/C substrate destruction during mitosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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