A Case of Ciprofloxacin-Induced QT Prolongation and Torsade de Pointes

Hedieh Keshavarz-Bahaghighat; Sheyda Najafi; Soha Namazi; Zahra Jahangard Rafsanjani

Journal of Pharmaceutical Care (Sep 2017)

A Case of Ciprofloxacin-Induced QT Prolongation and Torsade de Pointes

Hedieh Keshavarz-Bahaghighat,
Sheyda Najafi,
Soha Namazi,
Zahra Jahangard Rafsanjani

Affiliations

Hedieh Keshavarz-Bahaghighat: Tehran University of Medical Sciences, Faculty of Pharmacy, Department of Pharmaceutical Care, Imam Khomeini Hospital Complex
Sheyda Najafi: Tehran University of Medical Sciences, Faculty of Pharmacy, Department of Pharmaceutical Care, Imam Khomeini Hospital Complex
Soha Namazi: Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Zahra Jahangard Rafsanjani: Faculty of Pharmacy, Tehran University of Medical Sciences, Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran

Journal volume & issue: Vol. 4, no. 1-2

Abstract

Read online

Prolongation of the QT interval is a recognized adverse effect of fluoroquinolone antibiotics. This effect on ventricular repolarization can potentially lead to life-threatening arrhythmias such as Torsade de pointes. Torsade de pointes is a polymorphic form of ventricular tachycardia identified by twisting of the QRS axis around an isoelectric point. We report a case of torsade de pointes induced by ciprofloxacin treatment. The patient experienced an acquired QT interval prolongation followed by Torsade de pointes arrhythmia with ciprofloxacin administration for ileostomy closure surgery and unfortunately expired.

Published in Journal of Pharmaceutical Care

ISSN: 2322-4630 (Print); 2322-4509 (Online)
Publisher: Research Center for Rational Use of Drugs (RCRUD)
Country of publisher: Iran, Islamic Republic of
LCC subjects: Medicine: Therapeutics. Pharmacology; Medicine: Pharmacy and materia medica
Website: http://jpc.tums.ac.ir

About the journal

Abstract

Keywords