Diamond-Like Carbon Depositing on the Surface of Polylactide Membrane for Prevention of Adhesion Formation During Tendon Repair

Yao Xiao; Zaijin Tao; Yufeng Ju; Xiaolu Huang; Xinshu Zhang; Xiaonan Liu; Pavel A. Volotovski; Chao Huang; Hongqi Chen; Yaozhong Zhang; Shen Liu

doi:10.1007/s40820-024-01392-7

Nano-Micro Letters (Apr 2024)

Diamond-Like Carbon Depositing on the Surface of Polylactide Membrane for Prevention of Adhesion Formation During Tendon Repair

Yao Xiao,
Zaijin Tao,
Yufeng Ju,
Xiaolu Huang,
Xinshu Zhang,
Xiaonan Liu,
Pavel A. Volotovski,
Chao Huang,
Hongqi Chen,
Yaozhong Zhang,
Shen Liu

Affiliations

Yao Xiao: Department of Orthopaedics, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital
Zaijin Tao: Department of Orthopaedics, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital
Yufeng Ju: Shanghai Tongji Hospital
Xiaolu Huang: Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Research Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University
Xinshu Zhang: Department of Orthopaedics, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital
Xiaonan Liu: Department of Orthopaedics, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital
Pavel A. Volotovski: Orthopedic Trauma Department, Belarus Republic Scientific and Practical Center for Traumatology and Orthopedics
Chao Huang: Shanghai Haohai Biological Technology Limited Liability Company
Hongqi Chen: Department of General Surgery, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital
Yaozhong Zhang: Shanghai Key Laboratory for High Temperature Materials and Precision Forming, School of Materials Science and Engineering, Shanghai Jiao Tong University
Shen Liu: Department of Orthopaedics, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital

DOI: https://doi.org/10.1007/s40820-024-01392-7
Journal volume & issue: Vol. 16, no. 1
pp. 1 – 22

Abstract

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Highlights The anti-adhesion effect of polylactic acid (PLA) membrane with diamond-like carbon (DLC) depositing is 44.72%, enhanced by 23.11% compared to PLA. DLC deposited on PLA membranes has been shown to effectively reduce the levels of reactive oxygen species, leading to a decrease in the expression of pro-inflammatory cytokines within peritendinous adhesion tissue. DLC decelerates PLA biodegradation and lactic production, which reduces the number of CD68+CD206+ macrophages within peritendinous adhesion tissue.

Published in Nano-Micro Letters

ISSN: 2311-6706 (Print); 2150-5551 (Online)
Publisher: SpringerOpen
Country of publisher: Germany
LCC subjects: Technology
Website: http://www.springer.com/40820

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Abstract

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