Contribution of CRISPRable DNA to human complex traits

Ranran Zhai; Chenqing Zheng; Zhijian Yang; Ting Li; Jiantao Chen; Xia Shen

doi:10.1038/s42003-022-03969-7

Communications Biology (Oct 2022)

Contribution of CRISPRable DNA to human complex traits

Ranran Zhai,
Chenqing Zheng,
Zhijian Yang,
Ting Li,
Jiantao Chen,
Xia Shen

Affiliations

Ranran Zhai: Biostatistics Group, School of Life Sciences, Sun Yat-sen University
Chenqing Zheng: Biostatistics Group, School of Life Sciences, Sun Yat-sen University
Zhijian Yang: Biostatistics Group, School of Life Sciences, Sun Yat-sen University
Ting Li: Biostatistics Group, School of Life Sciences, Sun Yat-sen University
Jiantao Chen: Biostatistics Group, School of Life Sciences, Sun Yat-sen University
Xia Shen: Biostatistics Group, School of Life Sciences, Sun Yat-sen University

DOI: https://doi.org/10.1038/s42003-022-03969-7
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 8

Abstract

Read online

An analysis of different CRISPR protospacer-adjacent motifs (PAMs) from various Cas enzymes shows that GC-rich PAMs are more abundant in genomic regions that harbour enriched heritability for human complex traits.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal