Ultrasound-Induced Microbubble Cavitation for the Treatment of Catheterization-Induced Vasospasm

Shelby Kutty, MD, PhD, MHCM; Na Liu, MD, PhD; Jia Zhou, MD, PhD; Yunbin Xiao, MD, PhD; Juefei Wu, MD, PhD; David A. Danford, MD; John Lof, MS; Feng Xie, MD; Thomas R. Porter, MD

doi:10.1016/j.jacbts.2017.07.011

JACC: Basic to Translational Science (Dec 2017)

Ultrasound-Induced Microbubble Cavitation for the Treatment of Catheterization-Induced Vasospasm

Shelby Kutty, MD, PhD, MHCM,
Na Liu, MD, PhD,
Jia Zhou, MD, PhD,
Yunbin Xiao, MD, PhD,
Juefei Wu, MD, PhD,
David A. Danford, MD,
John Lof, MS,
Feng Xie, MD,
Thomas R. Porter, MD

Affiliations

Shelby Kutty, MD, PhD, MHCM: Division of Pediatric Cardiology, University of Nebraska College of Medicine/Children’s Hospital & Medical Center/Creighton University, Omaha, Nebraska
Na Liu, MD, PhD: Division of Pediatric Cardiology, University of Nebraska College of Medicine/Children’s Hospital & Medical Center/Creighton University, Omaha, Nebraska
Jia Zhou, MD, PhD: Division of Pediatric Cardiology, University of Nebraska College of Medicine/Children’s Hospital & Medical Center/Creighton University, Omaha, Nebraska
Yunbin Xiao, MD, PhD: Division of Pediatric Cardiology, University of Nebraska College of Medicine/Children’s Hospital & Medical Center/Creighton University, Omaha, Nebraska
Juefei Wu, MD, PhD: Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska
David A. Danford, MD: Division of Pediatric Cardiology, University of Nebraska College of Medicine/Children’s Hospital & Medical Center/Creighton University, Omaha, Nebraska
John Lof, MS: Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska
Feng Xie, MD: Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska
Thomas R. Porter, MD: Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska

DOI: https://doi.org/10.1016/j.jacbts.2017.07.011
Journal volume & issue: Vol. 2, no. 6
pp. 748 – 756

Abstract

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Inertial cavitation inducing ultrasound-mediated microbubble treatments can produce resolution of vasospasm and restoration of distal arterial flow after peripheral artery injury. Resolution of catheter-induced vasospasm is likely to be nitric oxide- mediated because improvements in stenosis diameter and downstream blood flow were blunted following pretreatment with L-NAME. The potential for clinical applicability of this therapy is significant because: 1) microbubbles can be delivered systemically into the site of injury enabling relatively high local concentration; 2) targeted transcutaneous ultrasound delivery is achievable due to the proximity of vessels; and 3) microbubbles and diagnostic ultrasound system used are commercially available.

Published in JACC: Basic to Translational Science

ISSN: 2452-302X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-basic-to-translational-science/

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Abstract

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