Applied Sciences (Oct 2021)

Co(II) Complex of Quercetin–Spectral, Anti-/Pro-Oxidant and Cytotoxic Activity in HaCaT Cell Lines

  • Monika Kalinowska,
  • Hanna Lewandowska,
  • Marek Pruszyński,
  • Grzegorz Świderski,
  • Ewelina Gołębiewska,
  • Kamila Gryko,
  • Julia Braun,
  • Monika Borkowska,
  • Magda Konieczna,
  • Włodzimierz Lewandowski

DOI
https://doi.org/10.3390/app11199244
Journal volume & issue
Vol. 11, no. 19
p. 9244

Abstract

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In this study a cobalt(II) complex of quercetin was synthetized in the solid state with the general formula Co(C15H9O7)2∙2H2O. The FT-IR, elemental analysis, and UV/Vis methods were used to study the composition of the complex in a solid state and in a water solution. The anti-/pro-oxidant activity of quercetin and the Co(II) complex was studied by means of spectrophotometric DPPH (2,2-diphenyl-1-picrylhydrazyl), FRAP (ferric reducing antioxidant activity) and Trolox oxidation assays. The cytotoxicity of quercetin and Co(II)-quercetin complex in HaCat cell lines was then established.

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