A Network-Level Stochastic Model for Pacemaker GABAergic Neurons in Substantia Nigra Pars Reticulata

Abstract

In this paper we present computational simulations of a mathematical model describing the time evolution of membrane potentials in a GABAergic neural network. This model, with stochastic and evolutionary characteristics, is an application of the version introduced previously where the authors present the continuous time version of a new class of stochastic models for biological neural networks. The goal is to computationally simulate the model (with the interaction conditions of a GABAergic network) and make biological inferences. More specifically, the computational simulations of the model that describe spiking neurons with electrophysiological characteristics of a brain region called substantia nigra pars reticulata, emphasize changes in desynchronized firing activity and how changes in individual activity propagate through the network.

Keywords

• stochastic model
• computational model
• GABAergic neurons
• substantia nigra pars reticulata