Neuromuscular Characteristics of Rocuronium in Diabetic Patients

Abstract

Purpose: In diabetic patients, there may be obsserved functional loss of motor nerve fibers and this fact may affect the management of anesthesia in many ways.In our study we aimed to research if there is any differences between non-diabetic patients and the patients who have type 2 diabetes on the side of nueromuscular blockade characteristics of rocuronium. Materials and method: 18 diabetic and 21 non-diabetic patients included to study, each patient evaluated by the NMT device after administiration of 0,6 mg/kg rocuronium intravenously.The onset of action time, clinical acting time , recovery time , total rocuronium dosage for each patient, amplitude of supramaximal excitation and Goldberg score were compared in the two groups. Results: Time of action (118,33+/-41,61 sn. and 142,00+/-28,68 sn.) and recovery time (13,33+/-9,83 dak. and 22,38+/-11,64 dak.) were longer than in diabetic patients (p0,05). Conclusion: We consider that the prolongation of onset of action time and recovery time in diabetic patients, is a complicaiton of diabetic neuropathy and diabetes may effect the pharmacodynamics of rocuronium. [Cukurova Med J 2014; 39(4.000): 807-813]

Keywords

• neuromuscular block
• rocuronium
• diabetes
• general anesthesia