One-Pot, Highly Stereoselective Synthesis of Dithioacetal-α,α-Diglycosides

Abstract

A one-step access to dithioacetal-α,α-diglycosides is reported. The synthetic strategy is based on the thioacetalization of aldehydes or ketones via highly stereoselective ring-opening of 1,6 anhydrosugars with bis(trimethylsilyl)sulfide.

Keywords

• glycomimetics
• thioglycosides
• dithioacetals
• 1,6-anhydrosugars
• ring-opening