Association of obstructive sleep apnea with cardiometabolic diseases and cardiovascular mortality

Abstract

Abstract Background Obstructive sleep apnea (OSA) is one of the leading respiratory disorders, increasing the risk of cardiometabolic diseases. In the study, we investigated the association between OSA and the risk of cardiometabolic diseases and all‐cause and cardiovascular mortality in adults. Methods Participants were enrolled in the National Health and Nutrition Examination Survey. The baseline covariates were compared between participants with and without OSA status. Multivariable logistic regression was performed to explore the association between OSA and cardiometabolic diseases, while Cox proportional regression was performed for all‐cause and cardiovascular mortality. Results OSA status was positively associated with higher risks of cardiometabolic diseases, including hypertension (odds ratio [OR] 1.28, 95% confidence interval [CI] 1.14–1.45; p < 0.001), diabetes (OR 1.46, 95% CI 1.22–1.76; p < 0.001), and cardiovascular diseases (OR 1.29, 95% CI 1.08–1.54; p = 0.006) after adjusting for numerous covariates. However, no associations of OSA with all‐cause or cardiovascular mortality were observed. Conclusion OSA was associated with a higher risk of hypertension, diabetes, and cardiovascular diseases, but had no significant association with all‐cause or cardiovascular mortality in adults.

Keywords

• cardiometabolic diseases
• cardiovascular diseases
• diabetes
• hypertension
• obstructive sleep apnea