IVABRADINE INFLUENCE ON SYSTOLIC AND DIASTOLIC FUNCTION OF HEART VENTRICLES IN PATIENTS WITH ISCHEMIC HEART DISEASE AFTER PRIMARY REVASCULARIZATION

Abstract

Aim. To compare effects of different medication therapy schedules on parameters of systolic and diastolic function of the left (LV) and right (RV) ventricles in patients with ischemic heart disease (CHD) after primary revascularization of myocardium (PPCI).Material and metods. The study was performed on two groups of CHD patients (n=32 and n=30, resp.) before and after PPCI. Systolic and diastolic function were assessed by ultrasound methods including doppler. In the 1st group during post-surgery period due to impossibility to titrate dosage of β-adrenoblokers and, respectively, achievement of CHD target heartrate, standard therapy was improved by ivabradin in dose 10-15 mg/day during 3 months.Results. Before operation in CHD patients’ diastolic dysfunction of LV and RV prevailed. PPCI and consequent medication therapy led to improve of systolic function of the LV and RV in both groups, however in the group additionally received ivabradin dynamic of the parameters was more prominet. In the 1st group, in contrast to 2st, also there was normalization of diastolic function of both ventricles.Conclusion. Adding of ivabradine to standard therapy of CHD patients after PPCI fulfills the efficacy for systolic LV and RV function and leads to normalization of their diastolic function.

Keywords

• iscemic heart disease
• primary myocardium revascularization
• ivabradine
• systolic and diastolic function of the left and right ventricles