Missed rifampicin and isoniazid resistance by commercial molecular assays

L Richards; F Ismail; J Nel; S V Omar

doi:10.7196/SAMJ.2024.v114i17.1779

South African Medical Journal (Jul 2024)

Missed rifampicin and isoniazid resistance by commercial molecular assays

L Richards,
F Ismail,
J Nel,
S V Omar

Affiliations

L Richards: ORCiD; Division of Infectious Diseases, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
F Ismail: ORCiD; Centre for Tuberculosis, National Institute for Communicable Diseases, Division of the National Health Laboratory Service, Johannesburg, South Africa; Department of Medical Microbiology, School of Medicine, University of Pretoria, South Africa
J Nel: Division of Infectious Diseases, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
S V Omar: ORCiD; Centre for Tuberculosis, National Institute for Communicable Diseases, Division of the National Health Laboratory Services, Johannesburg, South Africa, Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa and Department of Molecular Medicine, University of Witwatersrand, Johannesburg, South Africa; Department of Molecular Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

DOI: https://doi.org/10.7196/SAMJ.2024.v114i17.1779
Journal volume & issue: Vol. 114, no. 7

Abstract

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Drug-resistant tuberculosis (TB) has poor outcomes unless resistance is detected early, ideally by commercially available molecular tests. We present a case of occult multidrug-resistant TB where both rifampicin and isoniazid resistance were missed by molecular testing and were only identified by phenotypic testing.

Published in South African Medical Journal

ISSN: 0256-9574 (Print); 2078-5135 (Online)
Publisher: South African Medical Association
Country of publisher: South Africa
LCC subjects: Medicine: Medicine (General)
Website: https://samajournals.co.za/index.php/samj/index

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