Nature Communications (Jun 2022)

Gene expression signatures of individual ductal carcinoma in situ lesions identify processes and biomarkers associated with progression towards invasive ductal carcinoma

  • Clare A. Rebbeck,
  • Jian Xian,
  • Susanne Bornelöv,
  • Joseph Geradts,
  • Amy Hobeika,
  • Heather Geiger,
  • Jose Franco Alvarez,
  • Elena Rozhkova,
  • Ashley Nicholls,
  • Nicolas Robine,
  • Herbert K. Lyerly,
  • Gregory J. Hannon

DOI
https://doi.org/10.1038/s41467-022-30573-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

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Progression from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) remains poorly understood. Here, the authors analyse over 2700 micro-dissected samples using transcriptomics to identify genes that characterise different stages of DCIS to IDC progression, and identify IDC-associated markers within early-stage lesions.