Communications Biology (Jun 2022)

Sirt6-mediated epigenetic modification of DNA accessibility is essential for Pou2f3-induced thymic tuft cell development

  • Qian Zhang,
  • Jiayu Zhang,
  • Tong Lei,
  • Zhanfeng Liang,
  • Xue Dong,
  • Liguang Sun,
  • Yong Zhao

DOI
https://doi.org/10.1038/s42003-022-03484-9
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 14

Abstract

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Thymic epithelial cells (TECs) are essential for the production of self-tolerant T cells. Single-cell ATAC-seq of medullary TECs suggests that Sirt6-mediated epigenetic regulation may regulate the development of thymic tuft cells from these TECs.