Nature Communications (Jun 2021)
B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma
- Ayana T. Ruffin,
- Anthony R. Cillo,
- Tracy Tabib,
- Angen Liu,
- Sayali Onkar,
- Sheryl R. Kunning,
- Caleb Lampenfeld,
- Huda I. Atiya,
- Irina Abecassis,
- Cornelius H. L. Kürten,
- Zengbiao Qi,
- Ryan Soose,
- Umamaheswar Duvvuri,
- Seungwon Kim,
- Steffi Oesterrich,
- Robert Lafyatis,
- Lan G. Coffman,
- Robert L. Ferris,
- Dario A. A. Vignali,
- Tullia C. Bruno
Affiliations
- Ayana T. Ruffin
- Department of Immunology, University of Pittsburgh
- Anthony R. Cillo
- Department of Immunology, University of Pittsburgh
- Tracy Tabib
- Department of Medicine, University of Pittsburgh
- Angen Liu
- Department of Otolaryngology, University of Pittsburgh
- Sayali Onkar
- Department of Immunology, University of Pittsburgh
- Sheryl R. Kunning
- Department of Immunology, University of Pittsburgh
- Caleb Lampenfeld
- Department of Immunology, University of Pittsburgh
- Huda I. Atiya
- Hillman Cancer Center
- Irina Abecassis
- Department of Immunology, University of Pittsburgh
- Cornelius H. L. Kürten
- Department of Otorhinolaryngology, University Duisburg-Essen
- Zengbiao Qi
- Department of Medicine, University of Pittsburgh
- Ryan Soose
- Department of Otolaryngology, University of Pittsburgh
- Umamaheswar Duvvuri
- Hillman Cancer Center
- Seungwon Kim
- Department of Otolaryngology, University of Pittsburgh
- Steffi Oesterrich
- Hillman Cancer Center
- Robert Lafyatis
- Department of Medicine, University of Pittsburgh
- Lan G. Coffman
- Hillman Cancer Center
- Robert L. Ferris
- Department of Immunology, University of Pittsburgh
- Dario A. A. Vignali
- Department of Immunology, University of Pittsburgh
- Tullia C. Bruno
- Department of Immunology, University of Pittsburgh
- DOI
- https://doi.org/10.1038/s41467-021-23355-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Recent studies have highlighted the importance of B cells and tertiary lymphoid structures (TLS) in the modulation of anti-tumor immune responses. Here, the authors characterize how HPV status influences the phenotype of tumor infiltrating B cells in patients with head and neck squamous cell carcinoma and demonstrate that TLS with germinal centres are associated with better survival.
