Trisulfide Bond‐Mediated Molecular Phototheranostic Platform for “Activatable” NIR‐II Imaging‐Guided Enhanced Gas/Chemo‐Hypothermal Photothermal Therapy

Gui‐long Wu; Fen Liu; Na Li; Qian Fu; Cheng‐kun Wang; Sha Yang; Hao Xiao; Li Tang; Feirong Wang; Wei Zhou; Wenjie Wang; Qiang Kang; Zelong Li; Nanyun Lin; Yinyin Wu; Guodong Chen; Xiaofeng Tan; Qinglai Yang

doi:10.1002/advs.202304104

Advanced Science (Dec 2023)

Trisulfide Bond‐Mediated Molecular Phototheranostic Platform for “Activatable” NIR‐II Imaging‐Guided Enhanced Gas/Chemo‐Hypothermal Photothermal Therapy

Gui‐long Wu,
Fen Liu,
Na Li,
Qian Fu,
Cheng‐kun Wang,
Sha Yang,
Hao Xiao,
Li Tang,
Feirong Wang,
Wei Zhou,
Wenjie Wang,
Qiang Kang,
Zelong Li,
Nanyun Lin,
Yinyin Wu,
Guodong Chen,
Xiaofeng Tan,
Qinglai Yang

Affiliations

Gui‐long Wu: Center for Molecular Imaging Probe Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 China
Fen Liu: Center for Molecular Imaging Probe Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 China
Na Li: Center for Molecular Imaging Probe Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 China
Qian Fu: Center for Molecular Imaging Probe Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 China
Cheng‐kun Wang: Center for Molecular Imaging Probe Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 China
Sha Yang: Center for Molecular Imaging Probe Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 China
Hao Xiao: Center for Molecular Imaging Probe Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 China
Li Tang: Center for Molecular Imaging Probe Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 China
Feirong Wang: Center for Molecular Imaging Probe Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 China
Wei Zhou: Center for Molecular Imaging Probe Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 China
Wenjie Wang: Center for Molecular Imaging Probe Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 China
Qiang Kang: Center for Molecular Imaging Probe Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 China
Zelong Li: Center for Molecular Imaging Probe Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 China
Nanyun Lin: Center for Molecular Imaging Probe Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 China
Yinyin Wu: Center for Molecular Imaging Probe Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 China
Guodong Chen: Department of Hepatopancreatobiliary Surgery The First Affiliated Hospital Hengyang Medical School University of South China Hengyang Hunan 421001 China
Xiaofeng Tan: Center for Molecular Imaging Probe Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 China
Qinglai Yang: Center for Molecular Imaging Probe Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 China

DOI: https://doi.org/10.1002/advs.202304104
Journal volume & issue: Vol. 10, no. 36
pp. n/a – n/a

Abstract

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Abstract Tumor microenvironment (TME)‐triggered phototheranostic platform offers a feasible strategy to improve cancer diagnosis accuracy and minimize treatment side effects. Developing a stable and biocompatible molecular phototheranostic platform for TME‐activated second near‐infrared (NIR‐II) fluorescence imaging‐guided multimodal cascade therapy is a promising strategy for creating desirable anticancer agents. Herein, a new NIR‐II fluorescence imaging‐guided activatable molecular phototheranostic platform (IR‐FEP‐RGD‐S‐S‐S‐Fc) is presented for actively targeted tumor imaging and hydrogen sulfide (H2S) gas‐enhanced chemodynamic‐hypothermal photothermal combined therapy (CDT/HPTT). It is revealed for the first time that the coupling distance between IR‐FE and ferrocene is proportional to the photoinduced electron transfer (PET), and the aqueous environment is favorable for PET generation. The part of Cyclic‐RGDfK (cRGDfk) peptides can target the tumor and benefit the endocytosis of nanoparticles. The high‐concentration glutathione (GSH) in the TME will separate the fluorescence molecule and ferrocene by the GSH‐sensitive trisulfide bond, realizing light‐up NIR‐II fluorescence imaging and a cascade of trimodal synergistic CDT/HPTT/gas therapy (GT). In addition, the accumulation of hydroxyl radicals (•OH) and down‐regulation of glutathione peroxidase 4 (GPX4) can produce excessive harmful lipid hydroperoxides, ultimately leading to ferroptosis.

Published in Advanced Science

ISSN: 2198-3844 (Online)
Publisher: Wiley
Country of publisher: Germany
LCC subjects: Science
Website: https://onlinelibrary.wiley.com/journal/21983844

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