Neuropsychiatric Disease and Treatment (Oct 2019)
Clozapine As Transformative Treatment In Bipolar Patients
Abstract
Alina Wilkowska, Wiesław J Cubała Department of Psychiatry, Medical University of Gdańsk, Gdańsk, PolandCorrespondence: Alina WilkowskaDepartment of Psychiatry, Medical University of Gdańsk, Dębinki 7, Gdańsk 80-211, PolandTel +48 58 349 2650Fax +48 349 2748Email [email protected]: Clozapine is an atypical antipsychotic used in treatment-resistant bipolar disorder. There is evidence for its anti-suicidal, anti-aggressive properties and efficacy in substance use comorbidities. Despite guidelines, the drug is used in 1.5% of bipolar patients only. Considering its effectiveness in treatment-resistant cases as well as its epigenetic effects it may become transformative treatment in bipolar disorder impacting the clinical course and psychosocial burden of the disease.Keywords: clozapine, transformative treatment, bipolar disorder, treatment resistance
