Novel role of spironolactone in the therapy of resistant hypertension: Spironolactone and resistant hypertension

Abstract

Spironolactone is a competitive nonselective mineralocorticoid receptor blocker with high affinity for aldosterone; therefore, it is widely used as a diuretic and antihypertensive. Because of these properties it is used in the treatment of edema in congestive heart failure, liver cirrhosis with ascites and edema, nephrotic syndrome, malignant ascites, severe heart failure and primary hyperaldosteronism. Spironolactone is recommended for the treatment of resistant hypertension. Narrative review aims to present the pharmacodynamic and pharmacokinetic profile of spironolactone, and describe its position in the treatment of resistant hypertension.

Keywords

• spironolactone
• resistant hypertension
• cardiovascular system