Effectiveness of bronchial thermoplasty in patients with asthma exhibiting overweight/obesity and low quality of life

Kenta Nishi, MD; Chie Yoshimura, MD; Kyohei Morita, MD; Ryoichi Ishikawa, MD; Erika Toyokura, MD; Tadao Nagasaki; Hisako Matsumoto, MD, PhD; Yasuo Nishizaka, MD

World Allergy Organization Journal (Mar 2023)

Effectiveness of bronchial thermoplasty in patients with asthma exhibiting overweight/obesity and low quality of life

Kenta Nishi, MD,
Chie Yoshimura, MD,
Kyohei Morita, MD,
Ryoichi Ishikawa, MD,
Erika Toyokura, MD,
Tadao Nagasaki,
Hisako Matsumoto, MD, PhD,
Yasuo Nishizaka, MD

Affiliations

Kenta Nishi, MD: Department of Respiratory Medicine, Osaka Red Cross Hospital, Osaka, Japan; Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
Chie Yoshimura, MD: Department of Respiratory Medicine, Osaka Red Cross Hospital, Osaka, Japan
Kyohei Morita, MD: Department of Respiratory Medicine, Osaka Red Cross Hospital, Osaka, Japan
Ryoichi Ishikawa, MD: Department of Respiratory Medicine, Osaka Red Cross Hospital, Osaka, Japan
Erika Toyokura, MD: Department of Respiratory Medicine, Osaka Red Cross Hospital, Osaka, Japan
Tadao Nagasaki: Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; Corresponding author. Assistant Professor, Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
Hisako Matsumoto, MD, PhD: Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, Japan
Yasuo Nishizaka, MD: Department of Respiratory Medicine, Osaka Red Cross Hospital, Osaka, Japan

Journal volume & issue: Vol. 16, no. 3
p. 100756

Abstract

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Bronchial thermoplasty (BT) is effective in some severe asthma patients; however, the specific asthma phenotypes that produce a good response to BT are not fully understood. Clinical data were retrospectively reviewed in severe asthma patients who underwent BT at a single institution in Japan. At the follow-up assessment, the Asthma Quality of Life Questionnaire (AQLQ) scores (P = 0.003), maintenance oral corticosteroid doses (P = 0.027), and exacerbation frequency (P = 0.017) were significantly improved, while prebronchodilator-forced expiratory volume in 1 second (% predicted) did not significantly change (P = 0.19). When we grouped the patients into 2 groups according to their body mass index levels, the AQLQ scores were more improved in patients with overweight/obesity than those with normal weight (P = 0.01). This study showed that patients with non-controlled severe asthma exhibiting overweight/obesity and low quality of life had potential benefits from BT.

Published in World Allergy Organization Journal

ISSN: 1939-4551 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.sciencedirect.com/journal/world-allergy-organization-journal

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