Nature Communications (Jun 2018)
Recurrent rearrangements of FOS and FOSB define osteoblastoma
- Matthew W. Fittall,
- William Mifsud,
- Nischalan Pillay,
- Hongtao Ye,
- Anna-Christina Strobl,
- Annelien Verfaillie,
- Jonas Demeulemeester,
- Lei Zhang,
- Fitim Berisha,
- Maxime Tarabichi,
- Matthew D. Young,
- Elena Miranda,
- Patrick S. Tarpey,
- Roberto Tirabosco,
- Fernanda Amary,
- Agamemnon E. Grigoriadis,
- Michael R. Stratton,
- Peter Van Loo,
- Cristina R. Antonescu,
- Peter J. Campbell,
- Adrienne M. Flanagan,
- Sam Behjati
Affiliations
- Matthew W. Fittall
- The Francis Crick Institute
- William Mifsud
- University College London Cancer Institute
- Nischalan Pillay
- University College London Cancer Institute
- Hongtao Ye
- Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust
- Anna-Christina Strobl
- Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust
- Annelien Verfaillie
- The Francis Crick Institute
- Jonas Demeulemeester
- The Francis Crick Institute
- Lei Zhang
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Fitim Berisha
- Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust
- Maxime Tarabichi
- The Francis Crick Institute
- Matthew D. Young
- Wellcome Trust Sanger Institute
- Elena Miranda
- University College London Cancer Institute
- Patrick S. Tarpey
- Wellcome Trust Sanger Institute
- Roberto Tirabosco
- Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust
- Fernanda Amary
- Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust
- Agamemnon E. Grigoriadis
- Centre for Craniofacial and Regenerative Biology, King’s College London, Guy’s Hospital
- Michael R. Stratton
- Wellcome Trust Sanger Institute
- Peter Van Loo
- The Francis Crick Institute
- Cristina R. Antonescu
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Peter J. Campbell
- Wellcome Trust Sanger Institute
- Adrienne M. Flanagan
- University College London Cancer Institute
- Sam Behjati
- Wellcome Trust Sanger Institute
- DOI
- https://doi.org/10.1038/s41467-018-04530-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 6
Abstract
FOS has been linked to bone tumour pathogenesis, and viral homologue v-fos causes osteosarcoma in mice. Here, the authors report rearrangement of FOS and its paralogue FOSB in osteoblastoma and osteoid osteoma, revealing human bone tumours that are defined by mutations of FOS and FOSB.
