The SARS-CoV-2 Transcriptome and the Dynamics of the S Gene Furin Cleavage Site in Primary Human Airway Epithelia

mBio (Jun 2021)

Affiliations

Wei Zou: Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA
Min Xiong: Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA
Siyuan Hao: Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA
Elizabeth Yan Zhang: GeneGoCell Inc., San Diego, California, USA
Nathalie Baumlin: Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Michael D. Kim: Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Matthias Salathe: Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Ziying Yan: Department of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa, USA
Jianming Qiu: ORCiD; Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA

Abstract

Polarized human airway epithelia at an air-liquid interface (HAE-ALI) are an in vitro