Biosynthesis of thiocarboxylic acid-containing natural products

Liao-Bin Dong; Jeffrey D. Rudolf; Dingding Kang; Nan Wang; Cyndi Qixin He; Youchao Deng; Yong Huang; K. N. Houk; Yanwen Duan; Ben Shen

doi:10.1038/s41467-018-04747-y

Nature Communications (Jun 2018)

Biosynthesis of thiocarboxylic acid-containing natural products

Liao-Bin Dong,
Jeffrey D. Rudolf,
Dingding Kang,
Nan Wang,
Cyndi Qixin He,
Youchao Deng,
Yong Huang,
K. N. Houk,
Yanwen Duan,
Ben Shen

Affiliations

Liao-Bin Dong: Department of Chemistry, The Scripps Research Institute
Jeffrey D. Rudolf: Department of Chemistry, The Scripps Research Institute
Dingding Kang: Xiangya International Academy of Translational Medicine, Central South University
Nan Wang: Department of Chemistry, The Scripps Research Institute
Cyndi Qixin He: Department of Chemistry and Biochemistry, University of California
Youchao Deng: Xiangya International Academy of Translational Medicine, Central South University
Yong Huang: Xiangya International Academy of Translational Medicine, Central South University
K. N. Houk: Department of Chemistry and Biochemistry, University of California
Yanwen Duan: Xiangya International Academy of Translational Medicine, Central South University
Ben Shen: Department of Chemistry, The Scripps Research Institute

DOI: https://doi.org/10.1038/s41467-018-04747-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

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Thioplatensimycin (thioPTM) and thioplatencin (thioPTN) are recently discovered thiocarboxylic acid congeners of the antibacterial compounds PTM and PTN. Here, the authors identify a thioacid cassette encoding PtmA3 and PtmU4 that are responsible for carboxylate activation and sulfur transfer, respectively.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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