Regulation of mammalian 3D genome organization and histone H3K9 dimethylation by H3K9 methyltransferases

Kei Fukuda; Chikako Shimura; Hisashi Miura; Akie Tanigawa; Takehiro Suzuki; Naoshi Dohmae; Ichiro Hiratani; Yoichi Shinkai

doi:10.1038/s42003-021-02089-y

Communications Biology (May 2021)

Regulation of mammalian 3D genome organization and histone H3K9 dimethylation by H3K9 methyltransferases

Kei Fukuda,
Chikako Shimura,
Hisashi Miura,
Akie Tanigawa,
Takehiro Suzuki,
Naoshi Dohmae,
Ichiro Hiratani,
Yoichi Shinkai

Affiliations

Kei Fukuda: Cellular Memory Laboratory, RIKEN Cluster for Pioneering Research
Chikako Shimura: Cellular Memory Laboratory, RIKEN Cluster for Pioneering Research
Hisashi Miura: Laboratory for Developmental Epigenetics, RIKEN Center for Biosystems Dynamics Research
Akie Tanigawa: Laboratory for Developmental Epigenetics, RIKEN Center for Biosystems Dynamics Research
Takehiro Suzuki: Biomolecular Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science
Naoshi Dohmae: Biomolecular Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science
Ichiro Hiratani: Laboratory for Developmental Epigenetics, RIKEN Center for Biosystems Dynamics Research
Yoichi Shinkai: Cellular Memory Laboratory, RIKEN Cluster for Pioneering Research

DOI: https://doi.org/10.1038/s42003-021-02089-y
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 13

Abstract

Read online

Kei Fukuda et al. show that the formation of chromatin domains marked by dimethylated H3K9 is functionally linked to the 3D organization of the genome. These findings suggest that H3K9 methyltransferases play an important role in maintaining genome organization in more transcriptionally inactive compartments.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal